Earthworms for Ecology and Profit, vol. 1: Scientific by Gaddie R.E.

By Gaddie R.E.

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However, it is clearly separated from the blood by an apparent barrier with lipid characteristics. There- 2 I Multicompartment Models 47 fore. for lipid-soluble drugs the brain would probably be in the central compartment. whereas for more polar drugs the brain would probably be considered as part of a peripheral compartment. Hence, depending on the drug, the brain may be in the peripheral or in the central compartment. As with the one-compartment model, drug elimination in multicompartment systems is assumed to occur in a first-order fashion.

00855. o/ml 0 ~ u \-t o 1l2 = n min \ 10 a. 0 Time (hI Fig. 4 Plasma levels of pralidoxime after intravenous administration of the iodine salt to a healthy volunteer. The data (0) are described by a biexponential equation; the method of residuals has been applied. In the notation of the text, A, B, a, e, and Cp correspond to AI' A2, AI, A2. and C, respectively. 0 Experimental values, 0 residuals. (Data from Ref. 3. SUbject 2663, dose = 10 mg{kg. ) The zero-time intercept obtained by extrapolation of the terminal linear phase to t = 0 is An' Successive application of the method of residuals (Appendix C) will yield linear segment(s) with slope(s) and intercept(s) from which the remaining value(s) of A and A can be determined.

From Ref. ) of an antipyrine metabolite, 4-hydroxyantipyrine, versus time in individual patients. Application of the method of residuals (see Appendix C) in both instances will enable estimation of k m, the apparent first -order elimination rate constant of the metabolite. If, however, K is larger than k m, k m can be determined from the slopes of the terminal linear phases of these plots and K can be determined from the slopes of the residual lines. Without prior knowledge of either K or k m, one cannot tell whether the slope of the terminal linear segment of the urinary excretion-time plots yields K or km.

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