Drug Addiction: From Basic Research to Therapy by Per Svenningsson, Angus C. Nairn, Paul Greengard (auth.),

By Per Svenningsson, Angus C. Nairn, Paul Greengard (auth.), Dr. Rao S. Rapaka, Dr. Wolfgang Sadée (eds.)

Drug habit: From uncomplicated learn to Therapy offers a complete evaluation of physiological, biochemical, genetic and behavioral pathways underlying drug dependancy. targeting basic neurophysiological procedures that overlap among drug dependancy and different CNS problems, this quantity covers the interpretation of uncomplicated study into novel cures, not just of drug habit yet a spectrum of similar CNS issues, together with discomfort. Chapters are written by way of top scientists with broadly ranging services in artificial and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and improvement, drug concentrating on, and quantitative therapeutics, delivering an unparalleled evaluation of a posh box of excessive societal signficance.

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2001;98:11062-11068. 35. Liu F, Virshup DM, Nairn AC, Greengard P. Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. J Biol Chem. 2002;277:45393-45399. 36. Nishi A, Watanabe Y, Higashi H, Tanaka M, Nairn AC, Greengard P. Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc Natl Acad Sci USA. 2005;102:1199-1204. 37. Barnes NM, Sharp T. A review of central 5-HT receptors and their function.

Bristol-Myers to settle suits. Chem Eng News. 2003;81:6 2 Drug Discovery From Natural Sources 35 11. Oberlies NH, Kroll DJ. Camptothecin and taxol: historic achievements in natural products research. J Nat Prod. 2004;67:129-135. 12. Butler MS. Natural products to drugs: natural products derived compounds in clinical trials. Nat Prod Rep. 2005;22:162-195. 13. Dewick PM. Medicinal Natural Products: A Biosynthetic Approach. 2nd ed. Chichester, UK: John Wiley & Sons; 2002 14. Fabricant DS, Farnsworth NR.

2003;302:1412-1415. 46. Fienberg AA, Greengard P. The DARPP-32 knockout mouse. Brain Res Brain Res Rev. 2000;31:313-319. 47. Nairn AC, Svenningsson P, Nishi A, Fisone G, Girault JA, Greengard P. The role of DARPP32 in the actions of drugs of abuse. Neuropharmacology. 2004;47:14-23. 48. Valjent E, Pascoli V, Svenningsson P, et al. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci USA. 2005;102:491-496.

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