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Figures adapted from research papers published by the author and his coworkers are referenced in the legends. They were published in the journal Polymer and are reproduced by Permission of Butterworth-Heinemann Ltd. ) 39 References 1. P. Flory, Principles of Polymer Chemistry,Cornell University Press,Ithaca,NY, 1953. 2. Cowie,Polymers: Chemistry and Physics of Modern Materials,Blackie,Chapman and Hall,London,1973 and 1991. 3. ),Cyclic Polymers,Elsevier Applied Science,London,1986. 4. ,12,75(1958).
202. Stevenson,Brian Fender - H E reaching new heights, Chemistry in Britain, 30 December (1996). CHAPTER 2 CIRCULAR DNA Alexander V. Vologodskii, New York University, USA In 1963 by Dulbecco and Vogt  and Weil and Vinograd  discovered that double-stranded DNA of the polyoma virus exists in a closed circular form. At present it is generally acknowledged that this form is typical of bacterial DNA and of cytoplasmic DNA in animals. Furthermore, giant DNA molecules in higher organisms form loop structures held together by protein fasteners in which each loop is largely analogous to closed circular DNA.
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