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Extra info for Cocaine Abuse - Behavior, Pharmacology and Clin. Applns
Callahan, P. , & Cunningham, K. A. (1994). Discriminative stimulus properties of cocaine: Modulation by dopamine Dl receptors in nucleus accumbens. Psychopharmacology, 115, 110-114. Carlezon, W. A. , Devine, D. , & Wise, R. A. (1995). Habit-forming actions of nomifensine in nucleus accumbens. Psychopharmacology, 122, 194-197. , & Naylor, R. J. (1974). Extrapyramidal and mesolimbic involvement and the stereotypic activity of D- and L-amphetamine. European Journal of Pharmacology, 25, 121-129. 2 NEUROANATOMICAL BASES OF THE EFFECTS OF COCAINE IN THE R A T 4 5 Creese, L, & Iverson, S.
Coffin, V. , & Koob, G. R (1995). Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Research, 692, 47-56. Caine, S. , & Koob, G. P. (1994a). Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food. Journal of the Experimental Analysis of Behavior, 61, 213-221. Caine, S. , & Koob, G. P. (1994b). Effects of D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
1977), five rats that had acquired stable cocaine self-administration behavior under a fixed ratio (FR) 1 schedule subsequently received 6-OHDA infusions that depleted accumbens dopamine by an average of 90% relative to control animals. These accumbens-lesioned rats, but not rats with noradrenergic bundle lesions, exhibited significantly decreased cocaine self-administration relative to their prelesion cocaine intake. Importantly, subsequent studies indicated that dopaminergic depletions of the caudate nucleus failed to alter cocaine-maintained responding (Koob, Vaccarino, Amalric, & Bloom, 1987).