Ciba Foundation Symposium 79 - Biological Roles of Copper

Content:
Chapter 1 Chairman's advent (pages 1–3): Colin F. Mills
Chapter 2 nutritional assets of Copper (pages 5–22): H.T. Delves
Chapter three Absorption, delivery and Distribution of Copper (pages 23–48): Ian Bremner
Chapter four Metabolic Interactions of Copper with different hint parts (pages 49–65): Colin F. Mills
Chapter five Copper Proteins and Copper Enzymes (pages 71–91): A.E.G. Cass and H.A.O. Hill
Chapter 6 Caeruloplasmin: A Multi?Functional Metalloprotein of Vertebrate Plasma (pages 93–124): Earl Frieden
Chapter 7 Superoxide Dismutases (pages 125–142): Hosni Moustafa Hassan
Chapter eight Copper, Biogenic Amines, and Amine Oxidases (pages 143–161): T.L. Sourkes
Chapter nine Copper and the Synthesis of Elastin and Collagen (pages 163–182): Edward D. Harris, John okay. Rayton, James E. Balthrop, Robert A. Di Silvestro and Margaret Garcia?de?Quevedo
Chapter 10 Copper Deficiency in Ruminants (pages 183–207): Cecil H. McMurray
Chapter eleven Copper Deficiency in people (pages 209–225): David M. Danks
Chapter 12 Copper in Fetal and Neonatal improvement (pages 227–245): Lucille S. Hurley, Carl L. prepared and Bo Lonnerdal
Chapter thirteen Copper and Neurological functionality (pages 247–266): D.M. Hunt
Chapter 14 Copper and Hepatic functionality (pages 267–282): Charles A. Owen
Chapter 15 healing makes use of of Copper?Chelating brokers (pages 283–299): Ragnar Osterberg
Chapter sixteen Anaerobic Potentiation of Copper Toxicity and a few Environmental issues (pages 301–324): David C.H. McBrien
Chapter 17 Chairman's last comments (pages 325–330): Colin F. generators

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Extra resources for Ciba Foundation Symposium 79 - Biological Roles of Copper

Sample text

Perhaps he would comment briefly on the problem of Indian childhood cirrhosis, with its high accumulation of hepatic copper? S. Tanner, D. Pallot, S. Bulman, K. Ibe & T. King, unpublished work). X-ray dispersive microprobe analysis showed us that copper and sulphur were localized to these residual bodies, which presumably are responsible for the granular orcein staining seen in paraffin sections (Port- 40 DISCUSSION mann et a1 1978). Our problem with Indian childhood cirrhosis is that patients present at a late stage of the disease.

Biochem J 157:517-520 Bremner I , Hoekstra WG, Davies NT, Young BW 1978 Effect of zinc status of rats o n the synthesis and degradation of copper-induced metallothioneins. Biochem J 174:883-892 Carruthers ME, Hobbs CB, Warren RL 1966 Raised serum copper and caeruloplasmin levels in subjects taking oral contraceptives. J Clin Pathol 19:498-501 Cranfield LM, Gollan JL, White AG, Dormandy T L 1979 Serum antioxidant activity in normal and abnormal subjects. Ann Clin Biochem 16:299-306 El-Shobaki FA, Rummel W 1979 Binding of copper to mucosal transferrin and inhibition of intestinal iron absorption in rats.

Porter (1974) has suggested that much of the copper in neonatal bovine liver is present in the lysosomes, in a polymeric form of metallothionein. A significant amount of copper in the liver of copper-loaded animals may also occur in the lysosomes (Goldfischer & Sternlieb 1968, Evans 1973). 2) and were derived from lysosomes (King & Bremner 1979). Since we also detected sulphur within the residual bodies, the copper may have originated from metallothionein, which is rich in sulphur. In addition, these residual bodies were generally close to the portal tracts within the liver and they did not appear to be excreted in the bile.

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