By E. P. Abraham, G. G. F. Newton (auth.), David Gottlieb, Paul D. Shaw (eds.)
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Whoever desires to comprehend the genesis of contemporary technological know-how has to stick to 3 traces of improvement, all beginning in antiquity, that have been introduced jointly within the paintings of ISAAC NEWTON, particularly 1. old arithmetic => DESCARTES 2. historic Astronomy => COPERNICUS: I=> NEWTON three. old Mechanics => GALILEO => HUYGENS In technological know-how Awakening I (Dutch version 1950, first Eng1ish version 1954, moment 1961, first German variation 1956, moment 1965) i've got the 1st 1ine, giving an summary of the improvement of arithmetic in Egypt, Babylonia, and Greece.
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SPRECHER, D. B. SPRINSON, and B. D. DAVIS: The biosynthesis of shikimic from D-glucose. J. BioI. Chern. 220,477 (1956). STRATTON, CH. , and M. C. REBSTOCK: A new metabolite of Streptomyces venezuelae D-threo-1-p-aminophenyl-2-dichloroacetamido-1 ,3-propanediol. Arch. Biochem. Biophys. 103, 159 (1963). , T. TAZAKI, H. OKAMI, and S. FUKUYAMA: Isolation of a crystalline antibiotic substance from a strain of streptomyces and its identity with chloromycetin. Japan. Med. J. 1, 358 (1948). VINING, L. , and D.
4%. The direct incorporation of phenylalanine-P4C into gliotoxin was firmly established by degradation of the gliotoxin to indole-2-carboxylic acid (IV). Decarboxylation of the indole-2-carboxylic acid to indole and CO 2 demonstrated that all of the carbon-14 resided in the carboxyl group. :I ~NACOOH ~ Indole + COz H (IV) Further proof that all nine carbon atoms of phenylalanine, and not merely the aliphatic side chain, were incorporated into gliotoxin was provided by the isolation of gliotoxin-3 H after phenylalanine-U-3 H was added to growing cultures of T.
296, 18 (1963). , L. C. VINING, and R H. HASKINGS: Biogenetic studies on volucrisporin. Can. J. Chern. 40, 2357 (1962). , and R G. CHENOWETH: Biosynthesis of gliotoxin. 1. Incorporation of phenylalanine-1- and _2_14C. J. Am. Chern. Soc. 80, 4391 (1958). WEINDLING, R: Trichoderma lignorum as a parasite of other soil fungi. Phytopathology 22, 837 (1932). WEINDLING, R, and O. H. EMERSON: The isolation of a toxic substance from the culture filtrate of Trichoderma. Phytopathology 26, 1068 (1936). WINSTEAD, J.