Biomedical Applications of Peptide-, Glyco- and Glycopeptide by Jaroslav Sebestik, Milan Reinis, Jan Jezek

By Jaroslav Sebestik, Milan Reinis, Jan Jezek

Reaping rewards researchers in biochemistry and pharmacology, this booklet describes assorted different types of dendrimers, their biomedical and physico-chemical functions in addition to convergent and divergent syntheses, click on chemistry and ligation innovations.

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Extra info for Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures

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Another convincing example for a cluster effect in FimH binding was shown by employing mannosylated lysine-based MAGs [70]. The relative inhibitory potencies of the di-, tetra-, octa-, and hexadecavalent mannosylated MAGs increased with growing generations from 455 over 2000 and 3571 to 11111, respectively [44]. In spite of the fact that the avidity did not grow logarithmically, it rose to a much greater extent than it would by a linear increase with respect to the increasing valency. This increase of activity is called “cluster effect” or “multivalent effect” [10, 20, 34, 60, 63, 75, 87, 90, 91, 97, 116, 117, 126, 134].

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