This moment variation of the pioneering paintings in this scorching subject captures the key tendencies and most recent achievements within the artwork of uneven catalysis on an business scale. a few thoroughly new real-life case experiences written through the area leaders of their respective parts offer a compact and certified perception into this constructing box. The ensuing prepared reference and guide collates first-hand and useful details inside a context the place it may be simply found.
The high quality contributions illustrate the appropriate environments and events, corresponding to time strain, how the catalytic step suits into the general synthesis, or pageant with different artificial techniques, in addition to the common difficulties encountered within the a number of stages, together with finding/developing the catalyst and optimization of the method or collection of apparatus. either profitable and unsuccessful ways to resolve those difficulties are defined.
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Additional info for Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions, Second Edition
Introduction Table 1 New processes for existing active compounds (category I). Authors, Company Title Reaction, Emphasized topics J. Tao; J. Liu; Z. Chen Elevance Renewable Sciences, USA Some recent examples in developing biocatalytic pharmaceutical processes Nitrile and ester hydrolysis, aldol reaction Metagenomic approach, robust directed evolution, application to levetiracetam, atorvastatin, and pregabalin K. P¨untener, M. Scalone F. Enantioselective Hoffmann-La Roche, hydrogenation: applications Switzerland in process R&D of pharmaceuticals Asymmetric (transfer) hydrogenation of C = O and C = N bonds Process development, catalyst screening and optimization; scale-up to pilot, case studies (dibenzylpiperidin-3-one, 1,1,1-triﬂuoroacetone, levodione, dextromethorphan) W.
Second, to improve the therapeutic index and absorption, desorption, metabolism, excretion, and toxicity (ADMET) proﬁle, new chemical entities (NCEs) as pharmaceutical ingredients are structurally increasingly more complex, which conversely demand more selective transformations for bond connection and disconnection, manipulation of functional groups, and stereoselectivity. Third, catalytic process technology is posed to be the most crucial component in commercializing drug substances and even drug products as drug innovators or branded pharmaceutical companies are entering the generic business by launching generic versions of branded drugs.
De Vries DSM Pharmaceutical Products, The Netherlands M. Ikunaka, K. , Japan Asymmetric hydrogenation of a 2-isopropylcinnamic acid derivative en route to the blood pressure-lowering agent Aliskiren Ketone reduction, alcohol stereoinversion Overview of high-performance enzymatic technologies for industrial production of chiral alcohols Reduction of β-keto ester, transesteriﬁcation Route selection, process development, speedy scale-up Hydrogenation of α,β−unsaturated acid Ligands via parallel synthesis, highthroughput screening, ligand mixtures, process development, scale-up to pilot plant F.