Asthma and Allergic Diseases: Physiology, by Gianni Marone

By Gianni Marone

This booklet updates the former insurance of the mechanisms and mediators of bronchial asthma and its remedy. It offers articles by means of the major names within the box.

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38. 39. 40. 41. 42. GENETICS AND ASTHMA 21 relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma. Clin. Exp. Allergy 19:419-424, 1989. Levine, B. , Stember, R. H. and Fontino, M. Ragweed hayfever: genetic control and linkage to HL-A haplotypes. Science 178:1201-1203, 1972. Marsh, D. , Meyers, D. A. and Bias, W. B. The epidemiology and genetics of atopic allergy. N. Engl. J. Med. 305:1551-1559, 1981. Blumenthal, M. , Alper, C. and Yunis, E.

Mao, X. , Morimoto, K. and Hopkin, J. Association between atopic asthma and a coding variant of FceRI-/~ in a Japanese population. Hum. Mol. Genet. 5:1129-1130, 1996. 18. Marsh, D. , Neely, J. , Breazeale, D. , Freidhoff, L. , Krishnaswamy, G. and Beaty, T. H. 1 markers and total serum IgE concentrations. Science 264:1152-1155, 1994. 19. Myers, D. , Postma, D. , Panhuysen, C. I. , Amelung, P. , Levitt, R. C. and Bleeker, E. R. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5.

M. FceRI-/3 polymorphism and risk ofatopy in a general population sample. Br. Med. J. 311:776779, 1995. 15. Adra, C. , Rowley, J. D. and Lim, B. Cloning of the cDNA for a haemopoietic cell-specific protein related to CD20 and the beta subunit of the highaffinity IgE receptor: evidence for a family of proteins with four membrane spanning regions. Proc. Natl. Acad. Sci. 91:10178-10182, 1994. 16. Hill, M. R. and Cookson, W. O. C. M. A new variant of the/~ subunit of the high-affinity receptor for immunoglobulin E (Fc~RI-~ E237G): associations with measures of atopy and bronchial hyper-responsiveness.

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