Advances in Malignant Melanoma - Clinical, Research by A. Armstrong

By A. Armstrong

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Worldwide, Australia reports the highest incidences of melanoma (on the order of 40-60 cases per 100,000 individuals) due most likely to their geographic proximity to the equator and the high proportion of their population being fairskinned immigrants from Europe (Lens and Dawes, 2004). Race is the primary risk factor for developing melanoma, with fair-skinned races at greater risk than darker-skinned races. For example, fair-skinned Americans are 20 times more likely to develop melanoma than their dark-skinned counterparts (Fig.

2011). A flexible multiplex bead-based assay for detecting germline CDKN2A and CDK4 variants in melanoma-prone kindreds. J Invest Dermatol 131, 480-486. A. (2009). Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS 23, 385-393. , and Garbe, C. (2006). The incidence and mortality of cutaneous melanoma in Southern Germany: trends by anatomic site and pathologic characteristics, 1976 to 2003. Cancer 107, 1331-1339. M. (2010). Indoor tanning and risk of melanoma: a case-control study in a highly exposed population.

Mutat Res 1991;246:187-191. Pope SJ, Godar DE. (2010) Solar UV geometric conversion factors: horizontal plane to cylinder model. Photochem Photobiol. 86:457-466. Reichrath J, Rech M, Moeini M, Meese E, Tilgen W, Seifert M. 2007. In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells. Cancer Biol Ther 6:48-55 Roush GC, Schymura MJ, Holford TR. 1988. Patterns of invasive melanoma in the Connecticut Tumor Registry. Is the long-term increase real?

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